SOUTH AFRICAN VACCINATION SCHEDULE

(0) = Birth dose which doesn’t count as part of primary series

(1) = First dose in a series

(2) = Second dose in a series

(3) = Third dose in a series

(4) = Fourth dose - a booster

Diphtheria, Tetanus, Pertussis

combinations

Adacel quadra

Boostrix tetra

Diftavax

Hexaxim

Infanrix hexa

Tetraxim

​

Hepatitis A

Avaxim

Havrix

​

Hepatitis B

Heberbiovac

Engerix B

Euvax

​

Herpes Zoster ( Shingles)

Zostavax

​

Human papilloma virus (HPV)

Cervarix

Gardacil 9

Gardacil

Influenza

Influvac

Vaxigrip

Measles / MMR (measles mumps rubella)

Measbio (single measles)

Priorix (MMR)

Priorix tetra (MMRV)

Omzyta (MMR)

​

Meningococcal

Menactra

​

Pneumococcal

Prevnar

Pneumovax 23

Synflorix

​

Poliomyelitis

Oral polio vaccine

Inactivated polio vaccines, refer to the DTaP combinations

Rabies

Imogam ( immune globulin)

Imovax

Verorab

Rotavirus

Rotarix

Rotateq

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Tetanus / Tetanus & diphtheria combinations​

Tetavax

​

Tuberculosis

BCG

​

​

Varicella ( Chicken pox)

Onvara

Varilrix

Priorix tetra (MMR plus varicella)

DIPHTHERIA / TETANUS / PERTUSSIS COMBINATIONS

BOOSTRIX TETRA

INDICATION

INDICATION

GROWTH MEDIUMS & PROCESSING INGREDIENTS

INSERT

DTaP/IPV/HIB

Diphtheria, tetanus, acellular pertussis, hemophillus

influenza B

4 years and older as a booster following primary immunisation

1.5 mg aluminium phosphate,

vero ells,

formaldehyde,

neomycin,

streptomycin

polysorbate 80.

glutaraldehyde,

polymyxin B sulphate,

phenoxyethanol

DIFTAVAX

INDICATION

GROWTH MEDIUMS & PROCESSING INGREDIENTS

INSERT

Cannot locate insert

-

-

-

HEXAXIM

INDICATION

DTaP/IPV/HIB/ HEP B

Diphtheria, tetanus, acellular pertussis, hemophillus

influenza B, hepatitis B

Primary and booster vaccination from 6 weeks

GROWTH MEDIUMS AND PROCESSING INGREDIENTS

0.6mg aluminium hydroxide glutaraldehyde 

formaldehyde

neomycin

streptomycin

polymyxin B

vero cells

yeast

Hansenula polymorpha cells

INSERT

INFANRIX HEXA

INDICATION

DTaP/IPV/HIB/ HEP B

Diphtheria, tetanus, acellular pertussis, hemophillus

influenza B, hepatitis B

Primary and booster vaccination from 6 weeks

GROWTH MEDIUMS AND PROCESSING INGREDIENTS

0.5mg aluminum hydroxide

yeast cells

propagated in VERO cells

lactose

medium 199

disodium phosphate

formaldehyde, glutaraldehyde,

glycine

monopotassium phosphate

neomycin sulphate

polymyxin B sulphate

polysorbate 20

polysorbate 80

INSERT

TETRAXIM

INDICATION

DTaP

Diphtheria, tetanus, acellular pertussis.

Primary and booster vaccination from 6 weeks

GROWTH MEDIUMS AND PROCESSING INGREDIENTS

0.3mg aluminium hydroxide

vero cells

formaldehyde

phenoxyethanol,

glutaraldehyde 

neomycin

streptomycin

polymyxin B

INSERT

HEPATITIS A

AVAXIM 80

INDICATION

Hepatitis A

Primary vaccination children 12 months to 15 years

GROWTH MEDIUMS AND PROCESSING INGREDIENTS

(Saccharomyces cerevisiae)

MRC-5 human diploid cells

formaldehyde

hanks medium 199 polysorbate 80

INSERT

HAVRIX

INDICATION

Hepatitis A

Primary vacination 12 months of age and older

GROWTH MEDIUMS AND PROCESSING INGREDIENTS

MRC-5 human diploid cells

1ml adult dose 0.5 mg aluminum hydroxide

0.5ml pediatric dose 0.25mg aluminium hydroxide

Amino acid supplement

polysorbate 20

​neomycin sulfate

INSERT

HEPATITIS B

HEBERBIOVAC

INDICATION

Hepatitis B

GROWTH MEDIUMS AND PROCESSING INGREDIENTS

1ml adult dose

- 0.5mg aluminium hydroxide

- 0.05 mg thiomersal,

-yeast

0.5ml pediatric dose

-0.25 mg of aluminum hydroxide -0.025 mg thiomersal

-yeast

INSERT

Primary vaccination from birth

ENGERIX B

INDICATION

Hepatitis B

Primary vaccination from birth

GROWTH MEDIUMS AND PROCESSING INGREDIENTS

1 ml adult dose

-0.5 mg aluminum hydroxide.

0.5ml pediatric dose

-0.25 mg of aluminum hydroxide

yeast cells

INSERT

EUVAX

INDICATION

Hepatitis B

Primary vaccination from birth

GROWTH MEDIUMS AND PROCESSING INGREDIENTS

0.5mg aluminium hydroxide 0.01mg thimerosal

yeast cells (saccharomyces cerevisiae)

potassium phosphate monobasic

sodium phosphate dibasic

sodium chloride

​

INSERT

HERPES ZOSTER (SHINGLES)

ZOSTAVAX

INDICATION

Herpes zoster

Primary vacination 12 months of age and older

GROWTH MEDIUMS AND PROCESSING INGREDIENTS

porcine gelatin

bovine calf serum

monosodium L-glutamate

MRC-5 cells including DNA & protein

neomycin. 

INSERT

HUMAN PAPILLOMA VIRUS (HPV)

CERVARIX

INDICATION

human papillomavirus (HPV) types 16 & 18

GROWTH MEDIUMS AND PROCESSING INGREDIENTS

0.5 mg of aluminum

residual amounts of insect cell

residual amounts of viral proteins

residual amounts of bacterial cell protein

INSERT

Primary and booster vaccination for females  9 years to adults 45 years

GARDACIL 9

INDICATION

9-valent vaccine, human papillomavirus (HPV) types  6,11,16, 18, 31, 33, 45, 52, and 58

Primary and booster vaccination children 9 years to adults 45 years

GROWTH MEDIUMS AND PROCESSING INGREDIENTS

0.5 mg amorphous aluminum hydroxyphosphate sulfate (AAHS)

polysorbate 80

yeast cells (Saccharomyces cerevisiae)​

INSERT

GARDACIL

INDICATION

4-valent vaccine, human papillomavirus (HPV) types  6,11,16, 18

Primary vacination 12 months of age and older

GROWTH MEDIUMS AND PROCESSING INGREDIENTS

0.225 mg amorphous aluminum hydroxyphosphate sulfate (AAHS) 

polysorbate 80

yeast cells (Saccharomyces cerevisiae)

INSERT

INFLUENZA

INFLUVAC

INDICATION

Inactivated trivalent subunit influenza vaccine

For the "prevention" of influenza infection in adults and children from 3 years of age.

GROWTH MEDIUMS AND PROCESSING INGREDIENTS

Traces of eggs ( ovalbumin, chicken proteins)

formaldehyde

cetyltrimethylammonium bromide

polysorbate 80

gentamicin

INSERT

VAXIGRIP

INDICATION

Inactivated Influenza Vaccine Trivalent Types A and B (Split Virion)

6 months to 35 months receive two 0.25 ml doses one month apart.

36 months and older (one 0.5 ml dose. )

GROWTH MEDIUMS AND PROCESSING INGREDIENTS

egg protein

formaldehyde
octoxinol 9

neomycin

multidose vials contain thimerosal

INSERT

MEASLES & MMR

MEASBIO

INDICATION

Live attenuated measles virus

(CAM-70 strain) 

Children from 9 months of age, booster dose at 18 months.

A dose at 6 months of age is recommended for HIV positive patients.

GROWTH MEDIUMS AND PROCESSING INGREDIENTS

D-sorbitol

Lactose monohydrate

Gelatin

L-cysteine

phenol red

kanamycin sulphate

erythromycin

INSERT

PRIORIX (MMR)

INDICATION

Live attenuated measles (Schwarz strain) , mumps (RIT 4385 strain) and rubella (Wistar RA 27/3 strain) 

From 1 year onwards

GROWTH MEDIUMS AND PROCESSING INGREDIENTS

lactose

sorbitol

neomycin sulphate

human diploid MRC5 cells

chick embryos

INSERT

PRIORIX TETRA (MMRV)

INDICATION

GROWTH MEDIUMS AND PROCESSING INGREDIENTS

INSERT

Live attenuated

*Measles (Schwarz strain) , *Mumps (RIT 4385 strain) *Rubella (Wistar RA 27/3 strain) 

*Varicella virus ( OKA strain)

From 1 year onwards

Neomycin sulphate

produced on chick embryo cells

 human diploid (MRC-5) cells

OMZYTA (MMR)

INDICATION

GROWTH MEDIUMS AND PROCESSING INGREDIENTS

INSERT

Cannot locate insert

MENINOCOCCAL

MENACTRA

INDICATION

Neisseria meningitidis serogroups A, C, Y and W-135

Primary Vaccination:

• Children 9 through 23 months of age: Two doses, three months apart.

• Individuals 2 through 55 years of age: A single dose.

​

Booster Vaccination:

• A single booster dose may be given to individuals 15 through 55 years of age at continued risk for meningococcal disease, if at least 4 years have elapsed since the prior dose.

GROWTH MEDIUMS AND PROCESSING INGREDIENTS

formaldehyde

casein

INSERT

PNEUMOCOCCAL

PREVNAR

INDICATION

Pneumococcal 13-valent Conjugate Vaccine

Streptococcus pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F.

GROWTH MEDIUMS AND PROCESSING INGREDIENTS

0.125 mg aluminum phosphate

yeast extract,

soy peptone broth

casamino acids

INSERT

6 weeks to 5 years of age (prior to the 6th birthday)

PNEUMOVAX 23

INDICATION

Pneumococcal 23- valent unconjugated, polysaccharide vaccine

 Streptococcus pneumoniae serotypes : 1, 2, 3, 4, 5, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19A, 19F, 20, 22F, 23F, 33F

From 2 years onwards

GROWTH MEDIUMS AND PROCESSING INGREDIENTS

Phenol

INSERT

SYNFLORIX

INDICATION

10-valent pneumococcal polysaccharide conjugate vaccine

Streptococcus pneumoniae serotypes

1, 4, 5, 6B, 7F, 9V, 14, 18C, 19F, 23F and cross-reactive 19A

Primary vacination 6 weeks to 5 years

GROWTH MEDIUMS AND PROCESSING INGREDIENTS

0.5mg aluminium phosphate

INSERT

POLIOMYELITIS

BIVALENT ORAL POLIO

INDICATION

GROWTH MEDIUMS AND PROCESSING INGREDIENTS

INSERT

Sabin strains Type 1 (LSc, 2ab) and Type 3 (Leon 12a, 1b)

From birth

MRC5 human diploid cells

polysorbate 80

Neomycin sulphate

polymyxin B sulphate

phenol red

RABIES

IMOGAM

INDICATION

Rabies Immune Globulin (Human)

GROWTH MEDIUMS AND PROCESSING INGREDIENTS

pooled venous plasma of individuals immunized with rabies vaccine

prepared on human diploid cells

Warning: Products made from human plasma may carry a risk of transmitting infectious agents, eg, viruses, and theoretically, the Creutzfeldt-Jakob disease (CJD) agent.

INSERT

Indicated for individuals suspected of exposure to rabies

IMOVAX

INDICATION

Inactivated rabies virus

*Wistar Rabies Virus Strain PM-1503-3M

Indicated for children and adults. Pre or post- exposure to the rabies virus, as a primary vaccination or as a booster dose.

GROWTH MEDIUMS AND PROCESSING INGREDIENTS

MRC-5 human diploid cells

human albumin

neomycin sulfate

INSERT

phenol red 16 indicator

beta-propiolactone

VERORAB

INDICATION

Inactivated Rabies virus*, WISTAR Rabies PM/WI38 1503-3M strain

Indicated for children and adults. Pre or post- exposure to the rabies virus, as a primary vaccination or as a booster dose.

GROWTH MEDIUMS AND PROCESSING INGREDIENTS

Vero cells

maltose

20% human albumin solution

Basal Medium Eagle

INSERT

dextrose

amino-acids

L-Phenylalanine

ROTAVIRUS

ROTARIX

INDICATION

Rotavirus gastroenteritis caused by G1 and non-G1 types (G3, G4, and G9)

Oral vaccine for infants 6 weeks to 24 weeks of age

GROWTH MEDIUMS AND PROCESSING INGREDIENTS

vero cells

porcine circovirus type 1 253 (PCV-1)

Dulbecco’s Modified Eagle Medium

phenol red

sorbitol

sucrose

INSERT

ROTATEQ

INDICATION

Rotavirus gastroenteritis caused by types G1, G2, G3, G4, and G9.

Oral vaccine for infants 6 weeks to 32 weeks of age

GROWTH MEDIUMS AND PROCESSING INGREDIENTS

vero cells

fetal bovine serum

polysorbate 80

DNA from porcine circoviruses (PCV) 1 and 2,

INSERT

TETANUS

TETAVAX

INDICATION

Adsorbed tetanus toxoid vaccine

Pregnant woman

Primary immunisation:

2 successive injections one/two months apart followed by a booster 6 to 12 months after.

​

Booster injection:

1 dose10 years after primary immunisation and every 10 years thereafter.

GROWTH MEDIUMS AND PROCESSING INGREDIENTS

0.6 mg aluminum hydroxide

thimerosal,

INSERT

TUBERCULOSIS

BCG

INDICATION

Mycobacterium bovis BCG (Bacillus Calmette-Guerin), Danish strain 1331

From birth

GROWTH MEDIUMS AND PROCESSING INGREDIENTS

1 ml vaccine contains between 2 - 8 million bacteria

sodium glutamate

magnesium sulphate heptahydrate

dipotassium phosphate

l-asparagine monohydrate

ferric ammonium citrate

glycerol 85%

citric acid

monohydrate

water for injections.

INSERT

VARICELLA

ONVARA

INDICATION

GROWTH MEDIUMS AND PROCESSING INGREDIENTS

INSERT

Cannot locate package insert

VARILRIX

INDICATION

Inactivated Influenza Vaccine Trivalent Types A and B (Split Virion)

From 12 months of age

GROWTH MEDIUMS AND PROCESSING INGREDIENTS

 MRC5 human diploid cells

neomycin sulphate

​

INSERT